Imbruvica ibrutinib 140 mg is the trade name for the generic drug ibrutinib. In some cases, health care professionals may use the generic name ibrutinib when referring to the trade name Ibrutinib 140 mg.
Ibrutinib 140 mg is targeted therapy. Ibrutinib 140 mg inhibits the function of Bruton's tyrosine kinase (BTK). (For more detail, see "How this drug works," below.)
What Imbruvica Is Used For
- Chronic graft-versus-host (cGVHD) disease after failure of one or more prior lines of systemic therapy.
- Chronic lymphocytic leukemia (CLL) who have received at least one prior therapy.
- Mantle cell lymphoma (MCL) who have received at least one prior therapy.
- Marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy.
- Waldenstrom's macroglobulinemia
- Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.
How Ibrutinib 140 mg Is Given:
Ibrutinib 140 mg is a capsule, taken by mouth once daily. You may take 1-4 capsules at once depending on your prescribed dose.
Take Ibrutinib 140 mg at approximately the same time each day.
Take Ibrutinib 140 mg exactly as prescribed.
Swallow Ibrutinib 140 mg capsules whole with at least 8 ounces of water. Do not crush, open, chew or dissolve capsules.
Do not change your dose or stop Ibrutinib 140 mg unless your health care provider tells you to.
If you miss a dose of Ibrutinib 140 mg, it should be taken as soon as possible on the same day with a return to the normal schedule the following day. Do not take extra capsules of Ibrutinib 140 mg to make up the next dose.
Do not take more than 1 dose of Ibrutinib 140 mg at one time. Call your health care provider and go to the emergency room right away if you take too much ibrutinib cost in India.
Store at room temperature (68° F to 77° F); keep medication in original bottle; protect from high humidity, moisture and light.
Keep out of reach from children and pets.
Safely throw away any Ibrutinib 140 mg that is out of date or unused (ask your provider for directions on how to discard the medication).
The amount of Ibrutinib 140 mg that you will receive depends on many factors, including your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact Ibrutinib 140 mg dosage and schedule.
Important things to remember about the side effects of Ibrutinib 140 mg:
- Most people will not experience all of the Ibrutinib 140 mg side effects listed.
- Ibrutinib 140 mg side effects are often predictable in terms of their onset, duration, and severity.
- Ibrutinib 140 mg side effects are almost always reversible and will go away after therapy is complete.
- Ibrutinib 140 mg side effects may be quite manageable. There are many options to minimize or prevent the side effects of Ibrutinib 140 mg.
The following side effects are common (occurring in greater than 30%) for patients taking Ibrutinib 140 mg:
- Decreased platelets
- Decreased neutrophils
- Decreased hemaglobin
- Musculoskeletal pain
- Upper respiratory tract infection
- These are less common side effects (occurring in 10-29%) for patients receiving Ibrutinib 140 mg:
- Shortness of breath
- Abdominal pain
- Decreased appetite
- Urinary Tract Infection
- Skin infections
- Muscle spasms
Not all side effects are listed above. Some that are rare (occurring in less than about 10 percent of patients) are not listed here. Always inform your health care provider if you experience any unusual symptoms.
When to contact your doctor or health care provider:
Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:
Fever of 100.4° F (38° C or higher, chills)
Shortness of breath, cough, or trouble breathing
Any bleeding that won’t stop
The following symptoms require medical attention but are not an emergency. Contact your doctor or health care provider within 24 hours of noticing any of the following:
Diarrhea (4-6 episodes in a 24-hour period).
Blood in your stools or black stools
Headache that lasts a long time, confusion, change in your speech
Nausea (interferes with the ability to eat and unrelieved with prescribed medication).
Vomiting (vomiting more than 4-5 times in a 24 hour period).
Unable to eat or drink for 24 hours or have signs of dehydration: tiredness, thirst, dry mouth, dark and decrease amount of urine, or dizziness.
Skin or the whites of your eyes turn yellow
Urine turns dark or brown (tea color)
Pain on the right side of your stomach
Bleed or bruise more easily than normal
Any skin or nail changes (rash, itching, severe dryness, blisters, nail infection, inflammation of the lips, etc.)
Cough with or without mucus
Pain or burning with urination
Extreme fatigue (unable to carry on self-care activities)
Always inform your doctor or health care provider if you experience any unusual symptoms.
Do not drink grapefruit juice, eat grapefruit or eat Seville oranges (often used in marmalades) while you are taking Ibrutinib 140 mg. These products may increase the amount of Ibrutinib 140 mg in your blood.
Before starting Ibrutinib 140 mg treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
While taking Ibrutinib 140 mg, do not receive any kind of immunization or vaccination without your doctor’s approval.
Limit your time in the sun. Ibrutinib 140 mg can make your skin sensitive to sunlight. A severe sunburn, rash, or worsening acne can occur with too much exposure. Remember to use sunscreen and wear a hat and clothes that cover as much of your skin as possible while taking Ibrutinib 140 mg.
Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.)
For both men and women: Barrier methods of contraception, such as condoms, are recommended during therapy and for at least 2 weeks after treatment is complete. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
Do not breast feed while taking ibrutinib 140 mg in india price.
While taking Ibrutinib 140 mg, drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
Wash your hands often and after taking each dose of Ibrutinib 140 mg.
You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.
To help treat/prevent mouth sores while taking Ibrutinib 140 mg, use a soft toothbrush, and rinse three times a day with 1 teaspoon of baking soda mixed with 8 ounces of water.
Use an electric razor and a soft toothbrush to minimize bleeding.
Avoid contact sports or activities that could cause injury.
To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals while taking Ibrutinib 140 mg.
Eat foods that may help reduce diarrhea-see
Follow regimen of anti-diarrhea medication as prescribed by your health care professional.
Managing Side Effects - Diarrhea
Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing. Ibrutinib 140 mg may make you more sensitive to the sun and you may sunburn more easily.
In general, drinking alcoholic beverages should be kept to a minimum or avoided completely while you are taking Ibrutinib 140 mg. You should discuss this with your doctor.
Get plenty of rest.
Maintain good nutrition while being treated with Ibrutinib 140 mg.
If you experience symptoms or side effects while being treated with Ibrutinib 140 mg, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.
Monitoring and Testing:
You will be checked regularly by your doctor while you are taking Ibrutinib 140 mg to monitor side effects and check your response to therapy. Periodic blood work will be obtained to monitor the function of your organs (such as your kidneys and liver) as well as other side effects.
How Ibrutinib 140 mg Works:
Ibrutinib 140 mg is not a chemotherapy drug but one of what are termed "targeted therapies." Targeted therapy is the result of years of research dedicated to understanding the differences between cancer cells and normal cells. To date, cancer treatment has focused primarily on killing rapidly dividing cells because one feature of cancer cells is that they divide rapidly. Unfortunately, some of our normal cells divide rapidly too, causing multiple side effects.
Targeted therapy is about identifying other features of cancer cells. Scientists look for specific differences in the cancer cells and the normal cells. This information is used to create a targeted therapy to attack the cancer cells without damaging the normal cells, thus leading to fewer side effects. Each type of targeted therapy works a little bit differently but all interfere with the ability of the cancer cell to grow, divide, repair and/or communicate with other cells.
Ibrutinib 140 mg inhibits the function of Bruton's tyrosine kinase (BTK). BTK is a key signaling molecule of the B-cell receptor signaling complex that plays an important role in the survival of malignant B cells. Ibrutinib 140 mg blocks signals that stimulate malignant B cells to grow and divide uncontrollably.
Research continues to identify which cancers may be best treated with targeted therapies and to identify additional targets for more types of cancer.
Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this web site is meant to be helpful and educational, but is not a substitute for medical advice.